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Mechanistic plausibility is not clinical efficacy
Clinical trials have explored the safety profile of AOD and reported few adverse effects, such as insulin resistance or unwanted muscle growth, which are typically associated with traditional GH therapies (2)
Appetite hormones shift, satiety signals change, energy expenditure adapts, cravings can intensify, and the brains reward pathways do what they were designed to do: push you back toward your prior weight
There are no current published reports, only theory from pharmacokietics
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