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While the IOM had based B12 needs on the amount required to correct hematological parameters for people with pernicious anemia, the EFSA had almost 20 more years of research to draw on, and concluded that the most suitable approach was basing needs on biomarkers (serum B12, holotranscobalamin, MMA, and homocysteine)

Enhanced anastomotic strength could reduce leak rates following gastrointestinal surgery, while fistula healing effects might benefit patients with enterocutaneous or colocutaneous fistulas

Sub-spec marketplace product that started at 0.7% benzyl alcohol instead of 0.9%, or with pH outside the 4.5-7.0 range, doesn't get the full 28-day window even with perfect storage

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