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The key now is balancing enthusiasm with evidence as these investigational programs move through clinical trials
SMARCA4, SMARCB1, and PBRM1 are frequently mutated in 10% of patients with non-small lung adenocarcinomas 7 , and in almost patients with rhabdoid tumors, epithelioid sarcomas 8,9 , or in 40% of renal clear cell carcinomas 7
So a lot of this is forward-looking but theyre claiming its only a fraction of the billion people worldwide who have obesity that will take this, though they think it could grow to a hundred billion dollar market by 2030
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