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Despite being approximately 10-fold more resistant to arsenic than their parental cell line, PML/RAR protein was still degraded by As 2 O 3 in these cells, providing further evidence that loss of expression of the oncoprotein does not confer arsenic sensitivity

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The proton-motive force created by the ETC is also used for many additional mitochondrial processes, especially those related with transport across the IMM ( Although the primary function of mitochondria is to generate ATP as an energy molecule required for countless cell functions, a small fraction of electrons from the ETC are transferred directly to O 2 , resulting in the generation of the superoxide anion, which can give rise to other ROS as well as reactive nitrogen species (RNS)

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