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33 Similar findings were observed in a meta-analysis of 40 trials which concluded that GLP-1RAs were highly effective at lowering circulating glucose levels without causing hypoglycemia
SURPASS-CVOT does not redefine the hierarchy of CVOTs
remaining upright for 23 hours post-meal can reduce reflux and nausea Timing considerations can also help
A realistic oral titration schedule might look like: Week 1-4: 50 mg daily (equivalent to ~2.5 mg injected weekly) Week 5-8: 100 mg daily (equivalent to ~5 mg injected weekly) Week 9-12: 150 mg daily (equivalent to ~7.5 mg injected weekly) Each dose increase requires a larger absolute dose increment (50 mg, not 2.5 mg), which means each titration step exposes the patient to a larger pharmacokinetic jump
The Unified Parkinsons Disease Rating Scale (UPDRS): status and recommendations
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