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The overall hazard ratio (HR) estimate was 0.59 (95% CI 0.400.79), indicating that tirzepatide resulted from a significant reduction in the risk of MACE-4 compared to the control group [21]
Never recap needles, as this increases the risk of needlestick injury
Previous studies have also demonstrated that GLP-1R agonists exendin-4 (Ex4) induced diuresis and natriuresis by increasing GFR and inhibiting the main renal proximal tubule sodium reabsorption in normotensive rats (101, 102)
The catch is that GLP-1 receptors are found all over the gut, not just in the pancreas
doi: 10.1210/jcem.80.3.7883856 33 DruckerDJNauckMA
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