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Retatrutide is an investigational injectable medication developed by Eli Lilly for the treatment of obesity and overweight
For type 2 diabetes , NICE NG28 recommends continuing GLP-1 treatment only if there is adequate response, defined as HbA1c reduction of at least 11 mmol/mol (1.0%) and weight loss of at least 3% of initial body weight at 6 months
Joseph et al., 2011) and increased excitotoxicity (Rzheshevsky, 2014) (Figure 3)
Activation of the GLP-1 receptor (GLP-1R) by GLP-1 stimulates insulin release and inhibits glucagon secretion in a glucose-dependent manner
July 26, 2023
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