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Over 72 weeks, patients in the low-, medium- and high-dose orforglipron groups lost an average of 7.8%, 9.3% and 12.4% of their initial body weight, respectively, compared to 2.1% for the placebo group
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Experts note these symptoms can reflect underlying gastrointestinal changes linked to the drugs mechanism of action
Persistent nausea and vomiting : Inability to keep down fluids for more than 24 hours, or vomiting that prevents medication or food intake, requires medical assessment for dehydration and potential medication adjustment
Theyve even earned FDA approval for obesity treatment and are increasingly being prescribed for conditions like metabolic syndrome, prediabetes, and weight management
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