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But chronic high-dose use may: Overstimulate metabolic pathways Alter methylation balance (since NNMT is tied to methyl donor cycling) Lead to unintended side effects like fatigue, irritability, or hormonal imbalance Stick to researched dosing windows (typically 1020 mg/day for short cycles in animal models) 2
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With both compounds reducing energy intake (tirzepatide through appetite) and mobilizing stored energy (AOD 9604 through lipolysis), the body is working harder to maintain homeostasis
For example, those who follow vegan or vegetarian diets or are over the age of 60 may need supplementation (Pawlak, 2014
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