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Moreover, exposure to EEs has been closely associated with an increased incidence of hormone-dependent cancers, such as breast, endometrial, and testicular cancer [21,22,23]

Additionally, longitudinal studies are crucial for evaluating the efficacy and safety of these treatments, particularly in vulnerable populations, such as adolescents and individuals with pre-existing conditions

Data availability Although adequate data have been provided in the form of tables and figures, all authors declare that if more data are required, then the data will be provided on request

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