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Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice

The Role of Gut Health in Absorption Your supplements are only as good as your gut's ability to process them

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Curated data place Melanotan 1 as a full agonist at four subtypes with a clear order-of-magnitude preference for MC1R: pIC 10.0 at MC1R, pKi 8.9 at MC3R, pKi 8.5 to 8.8 at MC4R, pIC 9.0 at MC5R, and no activity at MC2R

Methods Enzymol 113:484490