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Peer review Peer review information Nature Medicine thanks Christiana Kartsonaki, Peter Rossing, Naveed Sattar and Vikas Sridhar for their contribution to the peer review of this work

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One notable difference is that tirzepatide is a dual-agonist (GLP-1 and GIP) while retatrutide is a triple-agonist (GLP-1, GIP, and glucagon)

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Cell Mol Neurobiol 34(7):925949 Rybka J, Kdziora-Kornatowska K, Bana-Leaska P et al (2013) Interplay between the pro-oxidant and antioxidant systems and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression

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Furthermore, cytokines regulate EC-SOD throughout mammalian tissues rather than specific cells responding to oxidants [84, 85]

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