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Participants in the SGLT2i group were less likely to require admission to hospital for any reason than those in the GLP-1 RA group (RR 0.59 [95% CI 0.46, 0.76] p 0.0001)
Physiology of peripheral and central GLP-1 signaling GLP-1 is a 30-amino acid peptide synthetized by enteroendocrine L cells of the small and large intestine, and also in the brain primarily by neurons of the nucleus tractus solitarius (NTS) within the caudal brainstem as a product of tissue-specific posttranslational cleavage of a larger precursor molecule preproglucagon (PPG)
Additionally, it effectively improves immune function, supports the replication of body cells, and helps the liver remove toxins from the body
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45 A review based on recent data using next-generation antibodies suggests that GLP-1R is not expressed in the human liver, regardless of its structural integrity
