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Glucagon-like peptide-1 agonist (GLP-1 agonist) is a class of drugs that reduce blood glucose and energy intake by activating the GLP-1 receptor

Clinical trials found nausea to peak following dose escalations, particularly above 8 mg

Structural diversity among agonist-bound states has been directly visualized by cryo-EM of GLP-1R in complex with multiple peptide agonists, confirming that conformational plasticity at the extracellular face propagates to the G protein interface in agonist-specific ways (Cary et al., 2021)

Anika Rao, MD, Board-Certified Internal Medicine

This is why some people wonder if BPC-157 might inadvertently boost tumor development