fda glp-1 news november 2025 ISPOR 2025: Exploring reasons for discontinuation FDA issued 25 warning letters

Hair grows slowly roughly half an inch per month and follicle cycling changes take weeks to manifest as visible density changes

Notably, Byetta was not approved as monotherapy initially (only as add-on), and it carried precautions about pancreatitis (we discuss safety later) and a note that it wasnt a substitute for insulin in type 1 diabetes

Nathan Kline Institute, Orangeburg, New York (Kantrowitz)

Ischemia-induced changes in glucagon-like peptide-1 receptor and neuroprotective effect of its agonist, exendin-4, in experimental transient cerebral ischemia

Beyond 12 weeks: continued improvement and plateau Months 3-6 (weeks 12-24): Continued gradual improvement Gains slowing (diminishing returns) Approaching maximum benefit Maintenance becomes focus Plateau timeline: Most people plateau around month 4-6 Maximum collagen density reached Further dosing maintains vs improves Some continue seeing minor gains to month 9-12 Long-term expectations (6-12 months): When to transition to maintenance: Achieved desired results No new improvements for 4+ weeks Comfortable with current appearance Want to reduce cost/frequency Maintenance dosing: Reduce from 3-5x weekly to 2-3x weekly Or reduce dose (2mg 1mg) Maintains results without continued improvement More sustainable long-term Factors affecting how quickly you see results Age and skin condition: Dose and frequency impact: Higher dose = faster results (to a point) Daily dosing faster than 2-3x weekly But diminishing returns above 3mg daily Consistency more important than dose Combination approaches: Injectable + topical: Fastest results GHK-Cu + retinol: Synergistic (separate timing) GHK-Cu + vitamin C: Enhanced collagen GHK-Cu + microneedling: Accelerated penetration Lifestyle factors: Sun protection: Critical (sun damages collagen faster than GHK-Cu builds it) Sleep: 7-9 hours optimizes cellular repair Hydration: 8-10 glasses water supports skin Diet: Protein intake supports collagen synthesis Stress: High cortisol impairs results See our peptides before and after results and can you use peptides and retinol together