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In 56-week studies, patients taking Contrave alongside diet and exercise lost an average of 5-9% of their body weight, compared to 1-5% with a placebo, meaning the medication contributed roughly 4-5 percentage points of additional weight loss.4,5 About 46% of patients on Contrave achieved at least 5% weight loss by week 16

Though there was no statistically significant difference in caregiver-rated Social Responsiveness Scale (SRS) in the group as a whole, there was statistically significant benefit in a subgroup of patients between ages 3-5

Interestingly, the results revealed that all four components inhibited both the monophenolase and diphenolase activity of tyrosinase, which had smaller molecular weights, correlating with greater tyrosinase inhibitory activity

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