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However, as millions of people begin GLP-1 therapy, questions about less common side effectsincluding musculoskeletal painhave surfaced

do not prolapse below the dentate line Grade II: prolapse out of the anal canal with defecation or straining but reduce spontaneously Grade III: prolapse out of the anal canal with defecation or straining and require manual reduction Grade IV: irreducible and may strangulate Internal hemorrhoids: Stool softeners, sitz baths Symptomatic treatment is usually all that is needed: stool softeners (e.g., docusate, psyllium), warm sitz baths (i.e., sitting in a tub of tolerably hot water for 10 min) after each bowel movement, and as needed, anesthetic ointments containing lidocaine, or witch hazel (Hamamelis) compresses

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Conclusion GLP-1 receptor agonists have been known for their potential to delay gastric emptying

The reasons for these differences may be related to the small sample size and the difference in drug intervention dose