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Additionally, increased MCP-1 levels are associated with heightened blood-brain barrier (BBB) permeability, further complicating disease pathology by allowing more inflammatory cells to infiltrate the CNS [26]
How Antioxidants Help : Green tea catechins, resveratrol, and other polyol-rich antioxidants help to modulate (manage) immune pathways, thereby reducing cytokine production and inflammation
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IRP2 expression is significantly upregulated in the midbrain substantia nigra of PD mice, increasing TFR1, FTH, and p53 levels, while decreasing SLC7A11 and GPX4 levels, leading to ferroptosis and disruption of the amino acid antioxidant system in dopaminergic neurons
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