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It means getting 1000 mcg (1 mg) of B12 injected once a week

Comparative Bioavailability and Utilization of Particular Forms of B12 Supplements With Potential to Mitigate B12-related Genetic Polymorphisms

Summary Interpretation The most defensible interpretation is that 5-Amino-1MQ is a small-molecule NNMT inhibitor that has been used in published preclinical research models without prominent severe acute toxicological signals described in the cited preclinical model reports under their specific tested conditions

And the position of the Pernicious Anaemia Society has always been that PA is more than just B12 deficiency

Others report improved focus, reduced brain fog, or simply feeling more like themselves. The effect varies by personsome feel it right away, while others see gradual improvement with consistent treatments