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In 1902 they discovered in anaesthetised dogs that a chemical messenger secreted by the intestinal lining into the bloodstream helped to stimulate the pancreas to produce digestive juices whenever food or acid was introduced into the duodenum

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Researchers theorize this may be one of the causes of various chronic pain syndromes, including neuropathy.[ref][ref] Celiac disease onset and progression: Researchers recently found that the severity of intestinal damage in celiac disease relates to the number of mast cells in the area

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