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2004 Jul;50(7):2130-9 Johe PD, Osterud B
Phe 28 of GLP-1 is critical for binding of GLP-1 to GLP-1R and interacts with Leu 32* , Thr 35 *, Val 36 * and Trp 39 *
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As in the previously mentioned study there was no difference between GLP-1 receptor agonists and SGLT2 inhibitors in reducing the risk of MACE, but when compared to DPP-4 inhibitors SGLT2 inhibitors significantly reduced cardiovascular and total death
These typically improve as time passes, but for others, the gut issues are potent enough to discontinue the medication
