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The most impressive structural feature of peptide 20 is the lipidated K10 P by a 16-carbon palmitic acid through a -carboxylate spacer, which perfectly inserted into the TM1-TM2 crevice and made extensive contacts with both receptors and lipid membrane to stabilize the binding poses (Fig

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Store it refrigerated at ~28C and use it within the working window commonly cited for reconstituted GLP-1-class peptides (up to ~4 weeks)

Readers are advised to check the MHRA and NICE websites regularly, as the regulatory and commissioning position may change

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