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The multiple cysteine residues on Keap1, which are ultrasensitive to electrophiles, are critically important for the binding with Nrf2 (Itoh et al., 1997, 1999
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The enzymes of the non-oxidative reactions of the PPP include transaldolase (encoded by the TALDO1 gene), transketolase (encoded by the TKT gene), ribose-5-phosphate isomerase (encoded by the RPIA gene), and ribulose-5-phosphate-3-epimerase (encoded by the RPE gene)
MJH and HTL contribute to this work equally
Afzali B, Lombardi G, Lechler RI, Lord GM
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