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Release probability of hippocampal glutamatergic terminals scales with the size of the active zone
Another classic example is AMB, a potent antifungal drug that, when administered intravenously, can cause severe adverse effects, including kidney, liver, and cardiovascular damage, as well as anemia and electrolyte imbalances (Jarvis et al., 2022)
For more on how fatty acid conjugation extends peptide half-life, see Peptide Half-Life Explained
But before assuming that a GLP-1 medication has stopped working, clinicians will typically consider how the patient is using the drug, such as whether its being taken properly, with little to no missed doses, and whether it is being stored properly