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injections of 100 nmol kg 1 PYY analogue ( n = 7 mice and n = 6 cages), 100 nmol kg 1 PYYMK-801 ( n = 7 mice and n = 4 cages), 100 nmol kg 1 GLP-1MK-801 ( n = 7 mice and n = 5 cages) or vehicle (isotonic saline, n = 7 mice and n = 4 cages) for 6 days

Multistage targeting strategy using magnetic composite nanoparticles for synergism of photothermal therapy and chemotherapy

Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces Alzheimer disease-associated tau hyperphosphorylation in the hippocampus of rats with type 2 diabetes

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10.1172/jci.insight.93382 Summary Keywords glucagon-like peptide-1 receptor agonists, ocular diseases, glaucoma, diabetic retinopathy, mechanism Citation Xie Z, Yang Z, Tian D and Chen Y (2025) Unlocking the potential of GLP-1 receptor agonists in ocular therapeutics: from molecular pathways to clinical impact