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It contains the active ingredient, retatrutide, and is being developed by the same manufacturer as Mounjaro, Eli Lilly, for the management of obesity and type 2 diabetes

A systemic autoimmune disease affecting the skin (dermatomyositis), the striated muscles (polymyositis), and often other targets (from the joints to the lungs)

Some comparisons, particularly those involving HOMA-IR, showed high heterogeneity and inconsistency, limiting interpretability

So Novo Nordisk went back to the drawing board and created semaglutide

Broadly, GLP-1 RAs activate neural signaling from the hypothalamus, resulting in increased secretion of neuropeptides, such as the gonadotropin releasing hormone, and various downstream effects on the hypothalamic-pituitary axis