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Calibrating expectations is part of responsible prescribing

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Given its high arginine content and polycationic nature, formulators typically account for hygroscopicity, potential trifluoroacetate counter-ion content from purification, and solubility behavior in aqueous versus mildly acidic reconstitution media when designing analytical experiments

114,220,223,224,225 Different CBS inhibitors have been designed and tested over the past years, starting with amino-oxyacetic acid (AOAA) 52,58,60 and related prodrugs