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Vasilakou et al., 2016)..Because the biological experiments provide the flux information needed to construct the models, accurate identification of metabolites and determination of flux changes is critical to the accuracy of subsequent predictions of network properties made using the models (Acosta et al., 2007)

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Until now, the cause of PD is unknown, but several factors seem to play a role, including environmental factors, such as the pesticide rotenone, that can block mitochondrial functions

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The phosphorylation of PDH inhibits its activity and, therefore, leads to decreased oxidation of pyruvate