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Cagrilintide layers on a smoother, portion-control style of fullness that many users describe as gentler on the stomach than ramping a single GLP-1 ever higher

Cancer Risk Elevated levels of insulin-like growth factor-1 (IGF-1), which is the downstream effect of GH activity, have also raised theoretical concerns about an increased risk of cancer: According to Roberts, IGF-1 promotes cellular proliferation and inhibits apoptosis, two mechanisms that may contribute to the development of cancer cells in predisposed individuals (22)

When applied to the skin, it may also cause mild skin or eye irritation ( Additionally, there is concern over mixing MSM with alcohol since other sulfur-containing medications can cause adverse reactions when mixed with alcoholic beverages ( However, no studies have explored this potentially problematic combination yet

doi:10.1128/AEM.60.5.1495-1499.1994

Another study found an average loss of 13 15 lb (about 6 7 kg) within the first 10 months