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Mulvihill EE, Drucker DJ (2014) Pharmacology, physiology, and mechanisms of action of dipeptidyl peptidase-4 inhibitors

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Leptin also reduces the levels of orexin, which is another peptide located in the same region and like MCH, induces hunger [28]

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This means that patients who have already been started on Wegovy or Zepbound for weight management in recent months may be eligible to transition to the Bridge without re-starting from scratch but the prescriber must complete a retrospective attestation of the qualifying BMI and clinical condition at the time of initial prescription

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Seiwerth S, Milavic M, Vukojevic J, et al

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In some cases, treatments such as topical therapies or other clinical options may support recovery, but most individuals see regrowth once weight stabilizes and internal balance returns

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