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Physiological and pharmacological mechanisms through which the DPP-4 inhibitor sitagliptin regulates glycemia in mice
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Cagrilintide mimics amylin, a hormone co-secreted with insulin from pancreatic beta cells, reducing food intake and delaying gastric emptying through a complementary but mechanistically distinct pathway
Simultaneously, insulin sensitivity can decline once GLP-1 support is removed, prompting the body to preferentially store energy as fat rather than burn it
Its manufacturer is careful to distinguish their device from microneedling, framing it as a delivery system rather than a wounding system
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