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Subcutaneous injection delivers approximately 100% of the administered dose into systemic circulation
The peptide is conjugated to a C20 fatty diacid moiety, a modification that supports extended biological activity in experimental systems and sustained receptor engagement across signaling pathways
Oral semaglutide titrated to 14 mg daily reduced 3-point MACE by 14% in SOUL (HR 0.86, 95% CI 0.770.96), with the principal driver a 26% reduction in nonfatal MI
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