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This paper is based on a presentation given at the Annual Meeting of the Society for the Study of Ingestive Behavior in July 2021 and provides a personal view on some of the milestones in the discovery of amylin as a constituent of pancreatic islet amyloid deposits, as a pancreatic beta-cell hormone, and on its role in physiology and pathophysiology

It achieves this by modulating the activity of various enzymes and growth factors involved in the wound healing cascade, including metalloproteinases, which are essential for breaking down and remodeling damaged tissue

However, any consideration of these peptides must come with medical oversight, safe sourcing, and clear understanding that they are still research products

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20.4% CagriSema Trial REDEFINE 2 (NEJM 2025) Duration 68 weeks Population T2D + BMI 27 (n=1,206) Mean Weight Loss 13.7% CagriSema vs 3.4% placebo