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The predominantly hepatic metabolism of orforglipron does, however, raise the question of whether dose adjustment is needed in hepatic impairment, an issue that was addressed in dedicated hepatic impairment studies during the clinical development program
The Image J software (Schneider et al., 2012) was used for image processing
The combination also seemed to help with some of the minor GI discomfort I experienced during Retatrutide dose escalation
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