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The science of slowed gastrointestinal motility GLP-1 receptor agonists act on the gutbrain axis and are known to slow gastric emptying and overall gastrointestinal transit , contributing to early satiety and appetite suppression. As intestinal transit slows, the colon has more time to absorb water from stool , leading to hard, dry stools that are difficult to pass . Constipation is a common, dose-related adverse effect listed in FDA prescribing information for both Wegovy (semaglutide) and Zepbound (tirzepatide) and is most frequently reported during dose escalation , with improvement over time., Step-by-Step MD Protocol for Relief 1
By stimulating insulin release and inhibiting glucagon, Tirzepatide helps stabilize blood sugar levels, reducing the risk of hyperglycemia, insulin resistance, and type 2 diabetes
This may require protein supplementation on days when appetite suppression is strongest
Typically, the most intense fatigue lasts for the first 4 to 8 weeks of treatment
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