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All authors commented on and critically revised the manuscript

The Nose-Hoover thermostat controlled the temperature in an NVT ensemble, with a simulation timestep of 1.0 fs and a total duration of up to 10 ps for system equilibration at the DFT level

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All of the studies used both in vivo and some form of in vitro methods of data collection in order to observe different treatment effects, allowing for biomechanical, functional (use of AFI index and load to failure), macroscopic and microscopic histological analysis

doi: 10.1155/2017/9584932 45 SzczepanowskiPNoszkaMya-UklejewiczDPikuaFNowaczyk-CieszewskaMet al