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Collectively, these results validate TMT-TAILs as an effective strategy for off-target substrate nomination and suggest that X(PC) induces a multipathway cell death response by cleaving endogenous caspase targets across both apoptotic and inflammatory pathways
The peptide's wound healing evidence is stronger than its cosmetic evidence, but neither has been validated through the rigorous clinical trials that established treatments like retinoids and vitamin C have undergone
Peer review Peer review information Nature Metabolism thanks Marie Migaud and the other, anonymous, reviewer(s) for their contribution to the peer review of this work
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