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Administering hepsin to wild-type mice increases APAP tolerance and downregulates GJ expression Considering the potential clinical and medical applications, we evaluated a therapeutic strategy involving the administration of hepsin to wild-type adult mice and assessed its potential to mitigate APAP-induced liver injury

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N Engl J Med 1999;340:1314-20

doi: 10.1136/BMJOPEN-2023-083550 93 MullerDRPStenversDJMalekzadehAHollemanFPainterRCSiegelaarSE

The resulting hypoxia and subsequent reperfusion induce oxidative stress, ROS, and increased inflammatory reactions