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In diabetic brains, these cytokines prompt the synthesis of ROS and trigger various cellular pathways such as advanced glycation end products (AGE), and protein kinase C (PKC) to cause neuroinflammation and neurodegeneration and ultimately CD (Zilliox et al., 2016)
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These are not interchangeable in mechanism
Additionally, a subcutaneous injection uses a shorter needle because it does not need to go deep into the tissues
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