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Meanwhile, the Subdoligranulum was significantly reduced in patients with DED ( Prevotella in the modulation of tear secretion among individuals suffering from DED and demonstrated a positive correlation between the severity of DED and the presence of Prevotella ( Research has indicated that dietary choices, particularly high-fat diets, significantly influence the gut microbiota, exacerbating DED symptoms through mechanisms such as decreased tear secretion, increased oxidative stress, and heightened apoptosis ( Deferribacterota in a mouse model of desiccation syndrome, closely correlating with increased severity of DED
Specifically, ALOXs facilitate the oxidation of PUFA or PUFA-containing lipids, thus contributing to ferroptosis [33]
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