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Other genes, although with ARE motifs, present CpG islands in their proximal promoters such as GCLC and GCLM, which are characterized by significant association of active histone codes such as H3K4Me1-3, H3K9Ac, H3K27Ac, and H3K79Me2, suggesting a regulatory role of CpG islands in chromatin modifications
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Cardiotoxicity attenuation has been studied in the context of bupivacaine exposure (PMID 27815173), broadening the literature beyond the conventional musculoskeletal and gastric framings
This mechanism of action helps to reduce body fat content and improve obesity symptoms
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