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Question 2: What is the significance of GGT in alcoholics

Some variants have clear structural explanations for their loss-of-function, for example, variants can disrupt binding of carnitine (R471C/H/P), affect the Na + -binding site (N32S), disrupt the TM2-TM11 H-bonding network (S467C) or perturb gating residues conserved in OCTs/OATs (R169Q/P/W)

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Serum leptin, adiponectin and ghrelin concentrations in post-menopausal women: Is there an association with bone mineral density?. Maturitas 88 (2016): 32-36

Expect social disclosure norms to evolve as well