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found that the combination of saquinavir, ritonavir, and rifampicin, may result in lower blood levels of saquinavir and ritonavir in patients (90)

For decades, patients have been warned about addiction risk, and as a result the drug is tightly regulated and generally prescribed for short-term use, with caution in patients with a history of substance abuse

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Severe and potentially fatal hypocalcemia (low blood calcium levels)

Since there is no standard dose of NAC, optimal dosing regimens have not been defined, and the exact dose of NAC needed for beneficial health effects in humans is unknown at this time