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Combining the two, especially in people with a history of pancreatitis or heavy drinking, creates a cumulative risk that exceeds either factor alone

Journal of Taibah University Medical Sciences, 17 (5), 785790

Protein While its rare to build muscle in a calorie deficit, eating enough protein helps maintain the muscle you have, leading to a leaner physique as you lose fat

NAION, A Rare but Serious Optic Nerve Risk One of the most discussed ocular concerns linked to GLP-1 therapy is non-arteritic anterior ischemic optic neuropathy, or NAION, sometimes described as an eye stroke. NAION occurs when blood flow to the optic nerve is suddenly reduced, causing painless but often permanent vision loss in one eye

Level of Evidence Summary: Diabetic Peripheral Neuropathy: Moderate ([1][6]) Peripheral Neuropathic Pain (General): Moderate[11] Fibromyalgia: Low to Moderate[7][8][9] Central Sensitization/Nociplastic Pain: Low to Moderate (Strong mechanistic rationale