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Disclosures Barnaby Hunt is an employee of Ossian Health Economics and Communications, which received consulting fees from Novo Nordisk A/S to support preparation of the analysis
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Adjusted mean weight loss was highest in the tirzepatide group (19.52 0.70 kg), followed by semaglutide (16.63 0.73 kg) and liraglutide (13.18 0.74 kg)
In addition, HEP-1 positively influenced gut microbiota diversity and richness by increasing the abundance of Dubosiella , Akkermansia and Lactobacillus , and reducing Bacteroides and Rikenellaceae RC9
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