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Kawano H, Yasue H, Kitagawa A, Hirai N, Yoshida T, Soejima H,

He points to a clinical trial published in The New England Journal of Medicine studying the impact of semaglutide in people who were diagnosed with both overweight or obesity and heart disease, but who had no history of diabetes

Signs of dehydration : decreased urination, dark urine, extreme thirst, dry mouth, or lightheadedness upon standing Severe gastrointestinal symptoms : persistent vomiting preventing fluid intake, bloody stools, or severe abdominal pain