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The lipidation step, common to both semaglutide and tirzepatide, adds an additional layer of chemical complexity

The foremost being that there is limited published research examining their combined effects

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We used two kinds of genetic instruments to proxy the exposure of GLP-1RAs, including expression quantitative trait loci of drugs target genes, and genetic variants within drugs target genes associated with glycated hemoglobin A1c(HbA1c) from genome wide association study

On patient safety and AE monitoring, we reviewed evidence from 2 systematic reviews and 6 real-world studies each including 500 or more patients, along with recommendations from 5 evidence-based clinical guidelines and 4 expert consensus documents