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This effector immune mechanism involving cytokines has received extensive attention in APAP-induced hepatotoxicity, in which DAMPs released by damaged hepatocytes act on pattern recognition receptors (PRRs) on macrophages and other potential cells, causing the production of pro-inflammatory cytokines and chemokines, thus promoting the inflammatory response [173]
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The peptide is available exclusively through 503A compounding pharmacies, where it is prescribed on an individual-patient basis without the pharmacokinetic characterization required of NDA-track drugs [8]
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