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Another study showed that metformin is associated with higher relative abundance of mucin-degrading Akkermansia muciniphila and Bifidobacterium bifidum (43, 48, 49) Both strains protected against NAFLD by activating hepatic FXR, suppressing intestinal FXR expression, modulating the gut microbiota, and improving intestinal mucosal permeability (50)
See the full bacteriostatic water guide for more details
This has been followed up with one clinical trial using oral SAMe supplementation
Afkarian, M
