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Lotte Bjerre Knudsen, Chief Scientific Advisor at Novo Nordisk, transformed this molecule into a viable drug through research on modifying GLP-1 by attaching a fatty acid

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The primary endpoint of weight loss of at least 5% occurred in 85% of the tirzepatide 5 mg group, 89% of the tirzepatide 10 mg group and 91% of participants in the tirzepatide 15 mg group

In cells exposed to high levels of oxidative stress, like red blood cells (RBC), up to 10% of the glucose consumption may be directed to the pentose phosphate pathway (PPP) for the production of the NADPH needed for this reaction

These effects are most pronounced during dose escalation and typically improve with time